Belimumab
Are you a clinician? See the clinical version of this page.
Given either as a drip into a vein (dose based on your weight, spaced out to every 4 weeks) or as a weekly injection under the skin. Tell your team about low mood or thoughts of self-harm, which have rarely been reported.
- Systemic lupus erythematosus (IV): A weight-based drip at weeks 0, 2, and 4, then every 4 weeks.
- Systemic lupus erythematosus (subcutaneous): A weekly injection under the skin.
Tests while you take it
Report signs of infection, and any new or worsening depression, anxiety, or thoughts of self-harm.
What to know
How it is used in lupus
Belimumab is added on top of the usual lupus medicines to lower disease activity and reduce flares, and it is one of the options used when lupus affects the kidneys.
Common side effects
The more common effects are reactions around the infusion or injection and a higher chance of infections. Some people notice mood changes, so your team will ask about your mood.
Tests and monitoring
Your team will check in about your mood, because new or worsening low mood or thoughts of self-harm have been reported with this medicine. Tell someone straight away if you notice these.
Before you start
As with other medicines that lower the immune system, your team will usually check for hepatitis B, tuberculosis, and HIV before you begin, and make sure your vaccines are up to date.
Important cautions
There is less information about belimumab in pregnancy, so the decision is made with you case by case. Your reviewed pregnancy guidance is on the separate pregnancy page. Live vaccines are generally not given while on this medicine.
What to watch for
- New or worsening low mood, or any thoughts of harming yourself. Seek help straight away.
- Signs of infection with a fever while on treatment. Contact your team.
- A reaction during or after a dose, such as rash, wheeze, or feeling faint.