For patients · Medication guide

Glucocorticoids

prednisone, prednisolone, steroids, corticosteroids

Are you a clinician? See the clinical version of this page.

The short versionSteroids such as prednisone are strong, fast-acting anti-inflammatory medicines. In inflammatory arthritis they are mainly used for a short time, to settle a flare or to bridge the gap while a disease-modifying medicine starts to work. They can also be given as an injection into a single inflamed joint.

How you take it

Steroids such as prednisone are strong, fast-acting anti-inflammatories, taken as tablets (or sometimes an injection or a drip). They settle inflammation quickly while slower medicines take effect, at the lowest dose and shortest time possible. Do not stop them suddenly.

Rheumatoid arthritis (bridging or flare): A low dose (often 5 to 10 mg a day) for a short time while your main medicine starts working.
Organ- or life-threatening disease (vasculitis, lupus nephritis): A higher dose to bring severe inflammation under control quickly, then reduced step by step.
Severe flare (pulse): A short course of high-dose steroid given by a drip in hospital.

Tests while you take it

With longer courses you will have checks on blood pressure, blood sugar, and bone health, and may be given calcium, vitamin D, or a bone medicine. Carry a steroid card and do not stop suddenly.

What to know

Common side effects

In the short term, steroids can increase appetite, affect sleep and mood, and raise blood sugar. Used for longer, they can thin the bones, raise the risk of infection, and affect the eyes, which is why the aim is to use the lowest dose for the shortest time.

Tests and monitoring

With longer use your team may check your blood pressure, blood sugar, and bone health, and consider medicines to protect your bones. Staying up to date with recommended vaccines is advised before starting where possible.

Important cautions

Steroids raise the risk of infections and can interact with other conditions such as diabetes. If you have been taking them for more than a short course, never stop them abruptly. Tell any healthcare professional treating you that you take steroids.

+Planning a pregnancy? This medicine has separate, reviewed reproductive-health guidance. See the pregnancy guide for this medicine.

iThis page helps you prepare a conversation with your care team. It does not replace individual medical advice. Always confirm your own plan with your rheumatology team.

What to watch for

Signs of infection such as fever, which steroids can mask. Seek advice early.
Symptoms of very high blood sugar such as a lot of thirst and passing urine often.
A severe change in mood.
Feeling very unwell if a longer course is stopped or missed, which needs urgent advice.