For patients
Methotrexate
MTX
Are you a clinician? See the clinical version of this page.
The short versionMethotrexate is stopped at least 3 months before you try to become pregnant, because it can harm a developing baby. Use reliable contraception while taking it. For men hoping to father a child, recent evidence is reassuring about low-dose methotrexate, though older advice was to stop it first; discuss your own situation with your team.
- Do not take methotrexate if there is any chance you could be pregnant.
- For fathers-to-be, low-dose methotrexate now appears compatible on current evidence.
Through your pregnancy journey
Stop pre-conception
Before pregnancy
Stopped at least 3 months before you try to conceive; keep using reliable contraception until then.
Avoid
First trimester
Not used in pregnancy.
Avoid
Second & third trimester
Not used in pregnancy.
Avoid
Breastfeeding
Avoided while breastfeeding. If no other option exists, discuss with your team.
Continue
For fathers-to-be
Recent evidence suggests low-dose methotrexate is compatible for fathers-to-be, though older advice was to stop it for 3 months. Discuss with your team.
iThis page helps you prepare a conversation with your care team. It does not replace individual medical advice. Always confirm your own plan with your rheumatology and pregnancy team.
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When to call your team
- Use reliable contraception while taking methotrexate.
- If you think you may be pregnant while taking methotrexate, contact your team promptly.
- Do not start trying to conceive until your team confirms it is safe to stop.