For patients
JAK inhibitors
tofacitinib, baricitinib, upadacitinib, filgotinib, JAKi
Are you a clinician? See the clinical version of this page.
The short versionJAK inhibitors are stopped before pregnancy and switched to a pregnancy-compatible medicine, because they are small molecules that cross to the baby and there is limited human data. Timing of stopping depends on the specific drug.
- Plan ahead so you can switch to a pregnancy-compatible medicine before trying to conceive.
Through your pregnancy journey
Stop pre-conception
Before pregnancy
Stopped before conception and swapped for a pregnancy-compatible option.
Avoid
First trimester
Not used in pregnancy.
Avoid
Second & third trimester
Not used in pregnancy.
Avoid
Breastfeeding
Usually avoided while breastfeeding.
Individualise
For fathers-to-be
For fathers-to-be, discuss with your team; data are limited.
iThis page helps you prepare a conversation with your care team. It does not replace individual medical advice. Always confirm your own plan with your rheumatology and pregnancy team.
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When to call your team
- Use reliable contraception while taking a JAK inhibitor.
- Tell your team before trying to conceive so your medicine can be changed in time.