For patients
IL-1 inhibitors
anakinra, canakinumab, anti-IL-1
Are you a clinician? See the clinical version of this page.
The short versionIL-1 inhibitors (used for autoinflammatory conditions like familial Mediterranean fever, Still's disease, and Behcet's) may be continued in pregnancy if needed to control your disease. They are considered compatible with breastfeeding.
- These are options for autoinflammatory conditions when colchicine is not enough.
Through your pregnancy journey
Use if needed
Before pregnancy
May be continued if needed to control autoinflammatory disease.
Use if needed
First trimester
Used if needed for disease control.
Use if needed
Second & third trimester
Used if needed for disease control.
Continue
Breastfeeding
Considered compatible with breastfeeding.
Continue
For fathers-to-be
Considered compatible for fathers-to-be.
iThis page helps you prepare a conversation with your care team. It does not replace individual medical advice. Always confirm your own plan with your rheumatology and pregnancy team.
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When to call your team
- Do not stop or start these medicines without your team.
- Tell your baby's team which biologics you took in pregnancy.