For patients

Cyclophosphamide

CYC, Cytoxan

Are you a clinician? See the clinical version of this page.

The short versionCyclophosphamide is avoided in early pregnancy because it can harm a developing baby, and it can affect fertility, so your team will discuss protecting your fertility before treatment. It is only considered later in pregnancy if a mother has severe, life-threatening disease.

Through your pregnancy journey

Stop pre-conception

Before pregnancy

Stopped before trying to conceive; talk to your team about protecting your fertility first.

Avoid

First trimester

Not used in early pregnancy.

Individualise

Second & third trimester

Only considered later in pregnancy if a mother is seriously unwell and needs it.

Avoid

Breastfeeding

Not compatible with breastfeeding.

Individualise

For fathers-to-be

Cyclophosphamide can cause lasting infertility in men, so sperm banking is offered before starting. It is not thought to harm a future baby through the father.

iThis page helps you prepare a conversation with your care team. It does not replace individual medical advice. Always confirm your own plan with your rheumatology and pregnancy team.
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