For patients
ANCA-associated vasculitis
ANCA vasculitis, GPA, granulomatosis with polyangiitis, MPA, microscopic polyangiitis, EGPA
Are you a clinician? See the clinical version of this page.
The short versionPregnancies in ANCA-associated vasculitis do best when the disease has been in remission for a good while before conceiving, on pregnancy-compatible medicines. Active disease, especially affecting the kidneys, carries more risk, so planning and close monitoring are key. Care is shared with a high-risk pregnancy team.
- Conceive when the vasculitis has been quiet for a good while.
- Rituximab is usually planned before pregnancy rather than during it.
What to know
Plan around remission
Aim to conceive after the vasculitis has been quiet for a good while, on medicines that suit pregnancy.
Kidney involvement
If your kidneys are affected, monitoring is especially close, because kidney inflammation can look like pre-eclampsia and the two need to be told apart.
Medicines
Rituximab is usually given before pregnancy. Azathioprine and steroids can be continued. Some strong medicines are avoided in pregnancy unless a mother is seriously unwell.
Monitoring in pregnancy
You will have close checks of blood pressure, urine, and kidney function, plus extra scans of the baby's growth.
iThis page helps you prepare a conversation with your care team. It does not replace individual medical advice. Always confirm your own plan with your rheumatology and pregnancy team.
!
When to call your team
- Blood in the urine, reduced urine, or new swelling.
- Severe headache or vision changes (possible pre-eclampsia).
- New breathlessness, coughing blood, or reduced baby movements.